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APOBEC3A overexpression has effect of HPV expression depend on cytidine deaminase. In SiHa cells, wt-A3A reduced the mRNA and protein expression of HPV16-E6 and HPV16-E7, whereas mut-A3A had no effect. In HeLa cells, wt-A3A inhibited the expression of HPV18-E6 at the levels of both mRNA and protein, but no effect on the expression of HPV18-E7. However, mut-A3A didn’t attenuate either HPV18-E6 or HPV18-E8.
