Table 1.
Characteristics of the selected studies evaluating PACG risk correlated with PCMTD1-ST18 rs1015213. Vithana’s article included 11 independent studies and Awadalla’s article included 2 independent studies
| Authors | year | country | population | matching variables | genotype | study design | outcomes | case | control | HWE Deviation |
|---|---|---|---|---|---|---|---|---|---|---|
| Awadalla (a) | 2013 | Australian | Caucasian | Gender-, ethnicity-matched | TT/CT+CC | case control | MAF | 232 | 288 | N |
| Awadalla (b) | 2013 | Nepalese | Asian | Gender-, ethnicity-matched | TT/CT+CC | case control | MAF | 106 | 204 | N |
| Duvesh | 2013 | India | Asian | Ethnicity-matched | TT/CT+CC | case control | MAF | 180 | 411 | N |
| Shi | 2013 | China (Jiangsu) | Asian | Age-, gender-matched | TT/CT+CC | case control | MAF | 453 | 599 | N |
| Vithana (a) | 2012 | Singapore (stage 1) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 983 | 943 | N |
| Vithana (b) | 2012 | Hong Kong (stage 1) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 297 | 1044 | N |
| Vithana (c) | 2012 | India (stage 1) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 338 | 2535 | N |
| Vithana (d) | 2012 | Malaysia (stage 1) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 83 | 3057 | N |
| Vithana (e) | 2012 | Vietnam (stage 1) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 153 | 2016 | N |
| Vithana (f) | 2012 | China (Beijing, stage 2) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 992 | 1667 | N |
| Vithana (g) | 2012 | Singapore (stage 2) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 304 | 1479 | N |
| Vithana (h) | 2012 | China (Shantou, stage 2) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 245 | 601 | N |
| Vithana (i) | 2012 | India (stage 2) | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 80 | 308 | N |
| Vithana (j) | 2012 | Saudi Arabia | Asian | Genetically-matched | TT/CT+CC | case control | MAF | 164 | 174 | N |
| Vithana (k) | 2012 | United Kingdom | Caucasian | Genetically-matched | TT/CT+CC | case control | MAF | 127 | 4701 | Y |
MAF: minor allele frequency, Nongpiur’s article included 4 independent studies; HWE: Hardy-Weinberg equilibrium.