Table 2.
Top 32 SNPs identified by genome-wide association study
| CHR | SNP | RS | BP | A1 | OR | L95 | U95 | P |
|---|---|---|---|---|---|---|---|---|
| 4 | SNP1 | NA | 136871784 | T | 3.178 | 1.907 | 5.295 | 9.06E-06 |
| 14 | SNP2 | NA | 47140657 | G | 4.307 | 2.241 | 8.277 | 1.18E-05 |
| 10 | SNP3 | rs1638410 | 118515516 | T | 4.454 | 2.24 | 8.857 | 2.05E-05 |
| 14 | SNP4 | rs9323332 | 58313237 | G | 2.919 | 1.776 | 4.799 | 2.40E-05 |
| 22 | SNP5 | rs1108364 | 46341876 | G | 2.686 | 1.697 | 4.25 | 2.46E-05 |
| 10 | SNP6 | rs11011962 | 20651003 | C | 2.867 | 1.757 | 4.678 | 2.50E-05 |
| 2 | SNP7 | NA | 170944892 | T | 4.986 | 2.359 | 10.54 | 2.59E-05 |
| 16 | SNP8 | rs4436775 | 54281857 | A | 2.66 | 1.686 | 4.198 | 2.63E-05 |
| 16 | SNP9 | rs4564560 | 54282265 | A | 2.618 | 1.672 | 4.102 | 2.63E-05 |
| 14 | SNP10 | NA | 47073011 | T | 6.163 | 2.636 | 14.41 | 2.71E-05 |
| 10 | SNP11 | rs10764221 | 20649311 | G | 2.859 | 1.748 | 4.675 | 2.86E-05 |
| 1 | SNP12 | rs4351663 | 83855776 | C | 6.458 | 2.676 | 15.58 | 3.32E-05 |
| 14 | SNP13 | rs10137341 | 46905759 | A | 3.639 | 1.972 | 6.714 | 3.58E-05 |
| 14 | SNP14 | NA | 47135262 | T | 4.028 | 2.077 | 7.812 | 3.73E-05 |
| 14 | SNP15 | NA | 47138095 | T | 4.028 | 2.077 | 7.812 | 3.73E-05 |
| 9 | SNP16 | rs72759216 | 125894343 | T | 3.07 | 1.791 | 5.263 | 4.53E-05 |
| 17 | SNP17 | NA | 70069186 | T | 2.668 | 1.661 | 4.284 | 4.92E-05 |
| 16 | SNP18 | rs11862589 | 54281443 | C | 2.53 | 1.614 | 3.966 | 5.17E-05 |
| 11 | SNP19 | rs340986 | 22463511 | T | 0.2363 | 0.1174 | 0.4755 | 5.26E-05 |
| 17 | SNP20 | rs55981110 | 70069449 | G | 2.594 | 1.634 | 4.119 | 5.35E-05 |
| 1 | SNP21 | rs34200648 | 44328065 | G | 3.372 | 1.863 | 6.103 | 5.94E-05 |
| 3 | SNP22 | NA | 177154093 | G | 3.142 | 1.791 | 5.513 | 6.57E-05 |
| 11 | SNP23 | rs1399096 | 22452671 | G | 0.2414 | 0.12 | 0.4858 | 6.79E-05 |
| 12 | SNP24 | rs11176925 | 66568062 | C | 2.981 | 1.741 | 5.102 | 6.84E-05 |
| 10 | SNP25 | rs11011954 | 20638640 | A | 2.89 | 1.708 | 4.893 | 7.73E-05 |
| 11 | SNP26 | rs1509728 | 108418533 | G | 2.494 | 1.583 | 3.93 | 8.11E-05 |
| 20 | SNP27 | rs7264385 | 57223196 | G | 2.94 | 1.717 | 5.037 | 8.59E-05 |
| 10 | SNP28 | rs987548 | 20639027 | G | 2.74 | 1.657 | 4.532 | 8.63E-05 |
| 11 | SNP29 | rs12799890 | 12490718 | G | 0.347 | 0.2043 | 0.5893 | 8.95E-05 |
| 23 | SNP30 | rs7051411 | 22358259 | A | 2.492 | 1.575 | 3.944 | 9.65E-05 |
| 7 | SNP31 | rs7796627 | 115873952 | T | 4.389 | 2.085 | 9.239 | 9.81E-05 |
| 3 | SNP32 | rs9822882 | 73736463 | A | 7.577 | 2.733 | 21.01 | 9.93E-05 |
A1, minor alleles. BP, Base pair position of the SNP. OR,odds ratio. OR and P werecalculated by an additive model in logistic regression analysis adjusted for chemo-regimens. MAF, minor allele frequency. L95, OR’s lower limitation for 95% CI. U95, OR’s upper limitation for 95% CI.