Table 3.

Meta-analysis of the association between MMP-12 82A/G polymorphism and cancer risk

Subgroup analysis	G allele vs A (Allele model)			GG+A/G vs AA (Dominant model)			GG vs A/G+AA (Recessive model)			GG vs AA (Homozygous model)			GG vs A/G (Heterozygous model)
	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
Number of studies		11			11			6			6			6
A>G	1	0.91-1.10	0.99	1.04	0.87-1.24	0.69	1.03	0.70-1.52	0.87	1.02	0.69-1.50	0.91	1.06	0.72-1.58	0.75
Ethnicity
Caucasians	0.94	0.84-1.06	0.32	0.93	0.82-1.06	0.28	0.99	0.66-1.51	0.98	0.98	0.64-1.48	0.91	1.05	0.68-1.60	0.83
Asians	1.09	0.89-1.35	0.41	1.16	0.81-1.66	0.42	1.98	0.42-9.32	0.38	1.97	0.42-9.28	0.21	2.19	0.47-10.29	0.17
Mixed	1.29	0.93-1.79	0.13	1.36	0.95-1.94	0.09	0.87	0.21-3.67	0.85	0.93	0.22-3.92	0.92	0.67	0.15-2.91	0.59
Genotype methods
PCR-RFLP	1.33	0.76-2.33	0.32	1.33	0.76-2.31	0.317		NA			NA			NA
Non-PCR-RFLP	0.96	0.85-1.09	0.55	0.96	0.85-1.09	0.554	1.03	0.70-1.52	0.88	1.02	0.69-1.50	0.92	1.06	0.72-1.58	0.75
Tumor type
CRC	0.9	0.70-1.15	0.41	0.86	0.65-1.13	0.275	1.24	0.54-2.86	0.61	1.18	0.51-2.74	0.69	1.43	0.60-3.39	0.42
LC	0.98	0.84-1.13	0.76	1	0.85-1.18	0.99	0.75	0.44-1.28	0.3	0.76	0.45-1.29	0.31		0.43-1.28	0.29
EOC	2.45	1.46-4.10	0.001	2.52	1.49-4.24	0.001		NA			NA		0.74	NA
ESCC	0.67	0.35-1.26	0.21	0.66	0.34-1.26	0.21		NA			NA			NA
EA	1.29	0.93-1.79	0.13	1.36	0.95-1.94	0.09	0.87	0.21-3.67	0.85	0.93	0.22-3.92	0.92	0.67	0.15-2.91	0.59
GCA	1.08	0.59-1.97	0.79	1.08	0.59-1.99	0.79		NA			NA			NA
HCC	1	0.60-1.68	0.99	1.04	0.62-1.76	0.88	0.37	0,02-9.08	0.54	0.37	0,02-9.12	0.54	0.35	0.01-8.80	0.51
BC	0.87	0.67-1.51	0.34	0.83	0.63-1.10	0.21	2.27	0.70-7.41	0.17	2.15	0.66-7.06	0.23	2.72	0.82-9.07	0.1
BRC	0.86	0.60-1.23	0.42	0.85	0.59-1.23	0.39	4.38	0.49-39.31	0.18	4.34	0.48-38.88	0.19	5.4	0.58-49.88	0.14

Note: W, wild allele; M, mutant allele; WW, wild homozygote; WM, heterozygote; MM, mutant homozygote; SNP, single-nucleotide polymorphism.