Table 3.
Subgroup analysis | G allele vs A (Allele model) | GG+A/G vs AA (Dominant model) | GG vs A/G+AA (Recessive model) | GG vs AA (Homozygous model) | GG vs A/G (Heterozygous model) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
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OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | |
Number of studies | 11 | 11 | 6 | 6 | 6 | ||||||||||
A>G | 1 | 0.91-1.10 | 0.99 | 1.04 | 0.87-1.24 | 0.69 | 1.03 | 0.70-1.52 | 0.87 | 1.02 | 0.69-1.50 | 0.91 | 1.06 | 0.72-1.58 | 0.75 |
Ethnicity | |||||||||||||||
Caucasians | 0.94 | 0.84-1.06 | 0.32 | 0.93 | 0.82-1.06 | 0.28 | 0.99 | 0.66-1.51 | 0.98 | 0.98 | 0.64-1.48 | 0.91 | 1.05 | 0.68-1.60 | 0.83 |
Asians | 1.09 | 0.89-1.35 | 0.41 | 1.16 | 0.81-1.66 | 0.42 | 1.98 | 0.42-9.32 | 0.38 | 1.97 | 0.42-9.28 | 0.21 | 2.19 | 0.47-10.29 | 0.17 |
Mixed | 1.29 | 0.93-1.79 | 0.13 | 1.36 | 0.95-1.94 | 0.09 | 0.87 | 0.21-3.67 | 0.85 | 0.93 | 0.22-3.92 | 0.92 | 0.67 | 0.15-2.91 | 0.59 |
Genotype methods | |||||||||||||||
PCR-RFLP | 1.33 | 0.76-2.33 | 0.32 | 1.33 | 0.76-2.31 | 0.317 | NA | NA | NA | ||||||
Non-PCR-RFLP | 0.96 | 0.85-1.09 | 0.55 | 0.96 | 0.85-1.09 | 0.554 | 1.03 | 0.70-1.52 | 0.88 | 1.02 | 0.69-1.50 | 0.92 | 1.06 | 0.72-1.58 | 0.75 |
Tumor type | |||||||||||||||
CRC | 0.9 | 0.70-1.15 | 0.41 | 0.86 | 0.65-1.13 | 0.275 | 1.24 | 0.54-2.86 | 0.61 | 1.18 | 0.51-2.74 | 0.69 | 1.43 | 0.60-3.39 | 0.42 |
LC | 0.98 | 0.84-1.13 | 0.76 | 1 | 0.85-1.18 | 0.99 | 0.75 | 0.44-1.28 | 0.3 | 0.76 | 0.45-1.29 | 0.31 | 0.43-1.28 | 0.29 | |
EOC | 2.45 | 1.46-4.10 | 0.001 | 2.52 | 1.49-4.24 | 0.001 | NA | NA | 0.74 | NA | |||||
ESCC | 0.67 | 0.35-1.26 | 0.21 | 0.66 | 0.34-1.26 | 0.21 | NA | NA | NA | ||||||
EA | 1.29 | 0.93-1.79 | 0.13 | 1.36 | 0.95-1.94 | 0.09 | 0.87 | 0.21-3.67 | 0.85 | 0.93 | 0.22-3.92 | 0.92 | 0.67 | 0.15-2.91 | 0.59 |
GCA | 1.08 | 0.59-1.97 | 0.79 | 1.08 | 0.59-1.99 | 0.79 | NA | NA | NA | ||||||
HCC | 1 | 0.60-1.68 | 0.99 | 1.04 | 0.62-1.76 | 0.88 | 0.37 | 0,02-9.08 | 0.54 | 0.37 | 0,02-9.12 | 0.54 | 0.35 | 0.01-8.80 | 0.51 |
BC | 0.87 | 0.67-1.51 | 0.34 | 0.83 | 0.63-1.10 | 0.21 | 2.27 | 0.70-7.41 | 0.17 | 2.15 | 0.66-7.06 | 0.23 | 2.72 | 0.82-9.07 | 0.1 |
BRC | 0.86 | 0.60-1.23 | 0.42 | 0.85 | 0.59-1.23 | 0.39 | 4.38 | 0.49-39.31 | 0.18 | 4.34 | 0.48-38.88 | 0.19 | 5.4 | 0.58-49.88 | 0.14 |
Note: W, wild allele; M, mutant allele; WW, wild homozygote; WM, heterozygote; MM, mutant homozygote; SNP, single-nucleotide polymorphism.