Table 3.
Univariate and multivariate Cox regression analysis for overall survival in glioma patients
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
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| Variate | No. of case (%) | Mean OS | 95% CI | P (log-rank) | Variate | RR | 95% CI | P |
| WHO grade | ≤0.001 | WHO grade | ≤0.001 | |||||
| II | 13 (17.1%) | 1947 | 1688-2205 | IV vs. III vs. II | 8.0 | 2.6-25.0 | ||
| III | 13 (17.1%) | 1330 | 936-1724 | |||||
| IV | 50 (65.8%) | 444 | 378-509 | |||||
| Age | ≤0.001 | Age | 0.055 | |||||
| >50 | 48 (63.2%) | 547 | 409-685 | >50 vs. ≤50 | 0.4 | 0.2-1.0 | ||
| ≤50 | 28 (36.8%) | 1378 | 1070-1686 | |||||
| Gender | 0.888 | Gender | 0.121 | |||||
| Male | 41 (53.9%) | 953 | 699-1208 | Male vs. Female | 1.6 | 0.9-3.0 | ||
| Female | 35 (46.1%) | 808 | 599-1017 | |||||
| KPS | ≤0.001 | KPS | 0.292 | |||||
| <90 | 42 (55.3%) | 505 | 405-605 | <90 vs. ≥90 | 1.5 | 0.7-3.0 | ||
| ≥90 | 34 (44.7%) | 1352 | 1057-1648 | |||||
| Surgical resection | 0.182 | Surgery | 0.232 | |||||
| GTR | 38 (50.0%) | 1018 | 753-1284 | PR vs. GTR | 1.4 | 0.8-2.6 | ||
| PR | 38 (50.0%) | 771 | 556-985 | |||||
| miR-105 expression | ≤0.001 | miR-105 expression | 0.018 | |||||
| Low | 47 (61.8%) | 426 | 362-490 | Low vs. High | 4.2 | 1.3-13.6 | ||
| High | 29 (31.2%) | 1618 | 1339-1896 | |||||
Abbreviations: KPS, Karnofsky performance scale; GTR, gross total resection; PR, partial resection; OS, overall survival; RR, risk ratio.