Table 3.
Performance of ARFI-induced SE, p-SWE, and their combined use in differentiating benign from malignant lesions in different size
| Groups | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) | YI | AUC | ||
|---|---|---|---|---|---|---|---|---|---|
| ≤ 10 mm | ARFI-induced SE | 64.9 (24/37) | 81.0 (17/21) | 70.7 (41/58) | 85.7 (24/28) | 56.7 (17/30) | 0.458 | 0.704 | |
| p-SWE | 59.5 (22/37) | 85.7 (18/21) | 69 (40/58) | 88 (22/25) | 54.5 (18/33) | 0.452 | 0.773 | ||
| ARFI-induced SE/p-SWE | 89.2a (33/37) | 61.9 (13/21) | 79.3 (46/58) | 80.5 (33/41) | 76.5 (13/17) | 0.511 | 0.755 | ||
| > 10 mm | ARFI-induced SE | 87.5 (21/24) | 93.2b (68/73) | 91.8 (89/97) | 80.8 (21/26) | 95.8 (68/71) | 0.807 | 0.912 | |
| p-SWE | 83.3 (20/24) | 82.2 (60/73) | 82.5 (80/97) | 60.6 (20/33) | 93.8 (60/64) | 0.655 | 0.844 | ||
| ARFI-induced SE/p-SWE | 100 (24/24) | 78.1 (57/73) | 81.4 (79/97) | 60.0 (24/40) | 100 (57/57) | 0.781 | 0.89 | ||
| Total | ARFI-induced SE | 73.8 (45/61) | 90.4d (85/94) | 83.9 (130/155) | 83.3 (45/54) | 84.2 (85/101) | 0.642 | 0.828 | |
| p-SWE | 82 (50/61) | 76.6 (72/94) | 78.7 (122/155) | 69.4 (50/72) | 86.7 (72/83) | 0.569 | 0.829 | ||
| ARFI-induced SE/p-SWE | 96.7c (59/61) | 71.2 (67/94) | 81.3 (125/155) | 68.6 (59/86) | 97.1e (67/69) | 0.68 | 0.84 | ||
Compared with sensitivity of ARFI-induced SE and p-SWE in nodules ≤ 10 mm, both P < 0.05.
Compared with specificity of ARFI-induced SE/p-SWE only in nodules > 10 mm, P < 0.01.
Compared with sensitivity of ARFI-induced SE and p-SWE in all nodules, both P < 0.01.
Compared with specificity of p-SWE and ARFI-induced SE/p-SWE in all nodules, both P < 0.05.
Compared with NPV of ARFI-induced SE and p-SWE in all nodules, both P < 0.05.
ARFI = acoustic radiation force impulse, SE = strain elastography, p-SWE = point shear wave elastography. PPV = positive predictive values, NPV = negative predictive values, YI = Youden index, AUC = area under the receiver-operating characteristic curve.