Table 3.
Genotype Frequencies and Allele Frequencies of 5 Single-Nucleotide Polymorphisms (SNPs) Between the Test Cases and Control Groups.
| Locus | Case (n = 125), n (%) | Control (n = 135), n (%) | OR (95% CI) | P Value |
|---|---|---|---|---|
| MTHFR 677C>T | ||||
| C | 150 (60.0) | 185 (68.5) | 1 | |
| T | 100 (40.0) | 85 (31.5) | 1.451 (1.012-2.081) | 0.043 |
| CC | 40 (32.0) | 60 (44.5) | 1 | |
| CT | 70 (56.0) | 65 (48.1) | 1.615 (0.957-2.727) | 0.072 |
| TT | 15 (12.0) | 10 (7.4) | 2.250 (0.920-5.504) | 0.072 |
| CT+TT | 85 (68.0) | 75 (55.5) | 1.700 (1.024-2.821) | 0.039 |
| MTHFR 1298A>C | ||||
| A | 204 (81.6) | 210 (77.8) | 1 | |
| C | 46 (18.4) | 60 (22.2) | 0.789 (0.514-1.213) | 0.28 |
| AA | 82 (65.6) | 78 (57.8) | 1 | |
| AC | 40 (32.0) | 54 (40.0) | 0.705 (0.422-1.177) | 0.18 |
| CC | 3 (2.4) | 3 (2.2) | 0.951 (0.186-4.855) | 0.952 |
| MTR 2756A>G | ||||
| A | 234 (93.6) | 238 (88.1) | 1 | |
| G | 16 (6.4) | 32 (11.9) | 0.509 (0.272-0.952) | 0.032 |
| AA | 109 (87.2) | 106 (78.5) | 1 | |
| AG | 16 (12.8) | 26 (19.3) | 0.598 (0.304-1.179) | 0.135 |
| GG | 0 (0.0) | 3 (2.2) | –a | –a |
| AG+GG | 16 (12.8) | 29 (21.5) | 0.537 (0.276-1.045) | 0.064 |
| MTRR 66A>G | ||||
| A | 193 (77.2) | 190 (70.4) | 1 | |
| G | 57 (22.8) | 80 (29.6) | 0.701 (0.473-1.041) | 0.077 |
| AA | 77 (61.6) | 68 (50.4) | 1 | |
| AG | 39 (31.2) | 54 (40.0) | 0.638 (0.377-1.079) | 0.093 |
| GG | 9 (7.2) | 13 (9.6) | 0.611 (0.246-1.519) | 0.286 |
| RFC-1 80A>G | ||||
| A | 114 (45.6) | 130 (48.1) | 1 | |
| G | 136 (54.4) | 140 (51.9) | 1.108 (0.785-1.564) | 0.561 |
| AA | 22 (17.6) | 26 (19.3) | 1 | |
| AG | 70 (56.0) | 78 (57.8) | 1.061 (0.552-2.038) | 0.86 |
| GG | 33 (26.4) | 31 (22.9) | 1.258 (0.594-2.664) | 0.548 |
Abbreviations: CI, confidence interval; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase; RFC-1, reduced folate carrier 1; OR, odds ratio.
aStatistical analyses were not performed because of limited data.