Table 1.
Histology and survival of cardiac allografts in recipients of co-transplanted heart and kidney allografts
| MHC mismatches |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor |
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| Kidney |
Heart allograft histology2 at week |
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| Group | Animal # | Mismatched cell type1 |
Heart | Parenchyma | Passengers | Recipient | 3 | 4 | 10 | 13 | 14 | 15 | 20 | 22 | 25 | >35 | Heart graft survival (days)3 |
Kidney allograft histology4 |
| 1 | 21421 | PCs & PLs | DD | AA | AA | CC | 3R | 28 | 3 | |||||||||
| 21692 | PCs & PLs | AA | DD | DD | CC | 3R | 32 | 1 | ||||||||||
| 21737 | PCs & PLs | AA | DD | DD | CC | 2R | 3R | 35 | 3 | |||||||||
| 25 | 21019 | none | DD | DD | DD | CC | 0 | 0 | 0 | 0 | >295 | 0 | ||||||
| 21018 | none | DD | DD | DD | CC | 0 | 1R | 0 | 0 | >284 | 0 | |||||||
| 20977 | none | DD | DD | DD | CC | 0 | 0 | 0 | 0 | >272 | 0 | |||||||
| 3 | 21407 | PCs alone | AC | AD | AC | AD | 2R | 2R | 1R | 110 | 0 | |||||||
| 21419 | PCs alone | AC | AD | AC | AD | 3R | 40 | 0 | ||||||||||
| 21501 | PCs alone | CC | AA | CC | AA | 3R | 26 | 0 | ||||||||||
| 4 | 21266 | PLs alone | AD | AD | AC | AC | 0 | 0 | 0 | 0 | 0 | 0 | >2546 | 0 | ||||
| 21270 | PLs alone | AD | AD | AC | AC | 1R | 1R | 0 | 0 | >1607 | 0 | |||||||
| 21517 | PLs alone | AD | AD | AC | AC | 0 | 1R | 0 | >150 | 0 | ||||||||
Animal #21407 and #21266 received chimeric kidneys from animal #20311. Animal #21419 and #21270 received chimeric kidneys from animal #20680. Animal #21501 received a chimeric kidney from animal #20407. Animal #21517 received a chimeric kidney from animal #21557.
PC, parenchyma cells; PL, passenger cells.
Grading of acute rejection from 0 (no rejection) to 3 (severe rejection) based on ISHLT scoring system (28).
Heart graft survival is significantly different between groups 1 versus 2; 1 versus 4; and 3 versus 4 (p<0.05, two-tailed Student’s t test). Heart graft survival is not significantly different between groups 1 versus 3 and 2 versus 4 (p>0.05, two-tailed Student’s t test).
Grading of T cell-mediated rejection from 0 (no rejection) to 3 (severe rejection) based on Banff classification (29) on kidney allografts at time of cardiac allograft rejection, kidney allograft removal, or euthanasia.
Previously published results (2).
Underwent donor kidney graftectomy on POD 141. Animal was sacrificed on POD254 to obtain final pathology.
Underwent donor-matched VCA transplantation on POD 131, sacrificed on POD160 since VCA rejected.