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. 2015 Sep 10;10(9):e0136932. doi: 10.1371/journal.pone.0136932

Fig 1. Depiction of the workflow.

Fig 1

Genes were selected based on their expression steady-state levels and their assigned function. RNA-Seq data and prior-knowledge were used as inputs for the NetGenerator. Using a mathematical modeling, a network was predicted, which was then evaluated and tested for robustness. A final model was selected, which led to new hypotheses that were experimentally validated.