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. 2015 Sep 10;10(9):e0136932. doi: 10.1371/journal.pone.0136932

Fig 7. Effects of different caspofungin concentrations on MAPK cascades.

Fig 7

(A) When caspofungin is used at inhibitory concentrations (1 μg ml-1), a repression of MpkA and SakA phosphorylation levels is observed. Under these conditions, the cellular transport is stimulated and the inhibition of MpkA and SakA avoids the turn-on of compensatory pathways. (B) The use of caspofungin at higher doses strongly activates MpkA and SakA. Under these conditions, cellular transport is inhibited and cell-wall compensatory pathways are more active.