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. 2015 Sep 10;10(9):e0135988. doi: 10.1371/journal.pone.0135988

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© 2015 Kabir et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — A. Recordings of left ventricular developed pressure (LVDP) comparing heart activity from wild-type (WT) animals not subjected to ischemia/reperfusion (Sham) with the function of hearts subjected to the ischemia reperfusion (I/R) protocol under the continuous presence of vehicle (control) or 40 nM E2 in KH buffer. In sham hearts, function stabilizes at about 30–40 min after mounting and is stable for at least 2 hours. In hearts subjected to I/R (middle and bottom traces), E2 improved recovery from ischemia (during reperfusion) compared to control. B-D. LVDP traces from hearts of Esr1, Esr2 and Gper1 knockouts (-/-) subjected to I/R. Only in Gper1^-/- hearts, E2 lost its ability to improve functional recovery (E). n = 6–8 hearts/ group.