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. 2015 Sep 10;10(9):e0135988. doi: 10.1371/journal.pone.0135988

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© 2015 Kabir et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — A. Ischemia/reperfusion (I/R) protocol used to perfuse mouse hearts isolated from WT, Esr1^-/-, Esr2^-/- and Gper1^-/- male animals. B-D. Time course of Rate Pressure Product (RPP) (B), Maximum Velocity of Contraction (dP/dt max) (C) and Minimum Velocity of Relaxation (dP/dt min) (D). During the reperfusion period, E2 produced an improvement of all of the functional recovery parameters compared to control in WT, Esr1^-/-, and Esr2^-/- (B-D, top); however, E2 had no effect when using Gper1^-/- hearts (B-D, bottom). Data points were obtained by averaging 2 min values before ischemia and every 10 min of reperfusion. Values are mean±SEM; * P<0.05 E2-treated versus control in WT; ⁺ P<0.05 E2-treated versus control in Esr2^-/-, ^# P<0.05 E2-treated versus control in Esr1^-/-. n = 6–8 hearts/ group.