Table 3. The comparison of skin permeation profiles of 5-aminolevulinic acid, tacrolimus, calcipotriol, and retinoic acid via control and psoriasis-like skins.
| Drug | Skin type | Control a | Psoriasis-like | Ratiopsoriasis/control b |
|---|---|---|---|---|
| ALA | Skin deposition (μg/mg) | 0.18±0.04 | 1.01±0.11 | 5.61 |
| Flux (μg/cm2/h) | 55.05±8.23 | 794.28±159.63 | 14.43 | |
| Follicular uptake (μg/cm2) | 1.35±0.16 | 5.17±0.55 | 3.83 | |
| Tacrolimus | Skin deposition (μg/mg) | 0.16±0.03 | 0.13±0.02 | 0.81 |
| Flux (μg/cm2/h) | 2.00±1.04 | 20.89±3.23 | 10.45 | |
| Follicular uptake (μg/cm2) | 1.29±0.16 | 2.12±0.77 | 1.64 | |
| Calcipotriol | Skin deposition (μg/mg) | 0.03±0.01 | 0.24±0.02 | 8.80 |
| Flux (μg/cm2/h) | ― c | 1.90±0.34 | ― | |
| Follicular uptake (μg/cm2) | ― | 0.91±0.06 | ― | |
| Retinoic acid | Skin deposition (μg/mg) | 0.21±0.05 | 0.34±0.03 | 1.66 |
| Flux (μg/cm2/h) | 0.19±0.06 | 0.73±0.12 | 3.75 | |
| Follicular uptake (μg/cm2) | 0.42±0.13 | 1.75±0.52 | 4.14 |
a The control group corresponds to the mice treated with the vehicle.
b Ratiopsoriasis/control, ratio of the permeation parameter of psoriatic skin/ permeation parameter of control skin.
c ―, not determined.
Each value represents the mean and S.D. (n = 4).