Table 2. List of most strongly up- and down-regulated microRNAs.
| 5 months vs. 6 weeks | |||||
| WKY | SHR | ||||
| fold | fold | ||||
| miRNA | array | PCR | miRNA | array | PCR |
| rno-miR-29b-3p | 4.1 | 2.2* | rno-miR-29b-3p | 4.2 | 4.2 |
| rno-miR-29a-3p | 2.5 | rno-miR-132-3p | 2.9 | 2.3 | |
| rno-miR-29c-3p | 2.3 | rno-miR-34a-5p | 2.6 | ||
| rno-miR-29c-5p | 2.0 | rno-miR-29a-3p | 2.6 | ||
| rno-miR-194-5p | 1.9 | rno-miR-29c-5p | 2.4 | ||
| rno-miR-222-3p | 1.8 | rno-miR-29c-3p | 2.4 | ||
| rno-miR-598-3p | 1.8 | rno-miR-145-3p | 2.1 | ||
| rno-miR-7a-5p | 1.8 | rno-miR-222-3p | 2.1 | ||
| rno-miR-101a-3p | 1.7 | rno-miR-598-3p | 2.0 | ||
| rno-miR-192-5p | 1.7 | rno-miR-30c-2-3p | 2.0 | ||
| rno-miR-322-3p | 0.5 | rno-miR-434-3p | 0.3 | ||
| rno-miR-127-3p | 0.4 | rno-miR-450a-5p | 0.3 | ||
| rno-miR-450a-5p | 0.4 | rno-miR-299a-5p | 0.3 | ||
| rno-miR-181c-5p | 0.4 | rno-miR-411-3p | 0.3 | ||
| rno-miR-411-3p | 0.4 | rno-miR-127-3p | 0.3 | ||
| rno-miR-299a-5p | 0.4 | rno-miR-136-5p | 0.3 | ||
| rno-miR-322-5p | 0.3 | rno-miR-379-5p | 0.2 | ||
| rno-miR-379-5p | 0.3 | rno-miR-542-3p | 0.2 | ||
| rno-miR-542-3p | 0.3 | rno-miR-322-5p | 0.2 | ||
| rno-miR-542-5p | 0.2 | 0.06* | rno-miR-542-5p | 0.1 | 0.02* |
| SHR vs. WKY | |||||
| 6 weeks | 5 months | ||||
| rno-miR-31a-5p | 5.8 | 5.5 | rno-miR-31a-3p | 2.8 | 7.8* |
| rno-miR-31a-3p | 3.5 | 16.9* | rno-miR-146a-5p | 0.5 | 0.3* |
The upper part lists miRNAs that are differentially expressed upon maturation in WKY and SHR (5 months vs. 6 weeks; adjusted P-value <0.05). Maturation shows many similarities in WKY and SHR, with some exceptions such as miR-132-3p. The lower part of the table shows a direct comparison between SHR and WKY, which yielded only 3 miRNAs that were significantly differentially expressed. Fold change obtained during PCR confirmation is also shown (* p <0.05, n = 5–6).