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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Ann N Y Acad Sci. 2015 Mar 10;1352(1):13–19. doi: 10.1111/nyas.12660

Figure 1.

Figure 1

Light-dependent regulation of RNA using photoswitchable proteins. (A) Protein-induced folding of a Spinach-based sensor to activate the DFHBI fluorescence. The sensor comprises a Spinach module (black), a transducer module (orange) and a protein-recognition module (blue). (B) An RNA aptamer (blue) that binds the light-activated conformation of a light-responsive protein is fused to a protein-inhibiting aptamer (black). Upon binding the light-activated protein, the aptamer (blue) then folds, enabling the protein-inhibiting aptamer (black) to fold and inhibit its target protein. The active aptamer is indicated with a green check mark.