Figure 3.

Multiple ASD-susceptibility genes are differentially expressed at both two and six weeks of age, in the direction suggested by the type of variant (t-tests, n = 3 biological replicates per genotype and age, * indicates FDR corrected p-value < 0.05, ** indicates p < 0.01, error bars represent s.e.m.). (a) Foxp2 is downregulated in Pten^m3m4/m3m4 mice, and deletions of the human gene are reported in ASD. (b) Msn levels are increased, and functional validation of a ncRNA upregulated in ASD indicates that its targeting of the human MSN gene leads to upregulation. (c) Minimal distance interaction network representing all AutDB genes differentially expressed in at least one comparison group (larger font size). Interaction partners that connect two AutDB genes are shown in small font sizes, and the log₂(fold-change) between wild-type and Pten^m3m4/m3m4 mice at 6 weeks is shown as node fill colors ranging from purple (upregulated) to green (downregulated). Membership in the gene ontology categories synaptic transmission and immune system process are indicated with node outline colors of orange and light blue, respectively.