Table 1.

Many genes reported as deleted in human ASD are downregulated in Pten^m3m4/m3m4 mice at 6-weeks of age. See Supplemental Table 2 for the full list of altered susceptibility genes, their primary references, and differential expression information for the 2-week old cohort.

AutDB Description		Ptenm3m4 Expression
Gene	Alteration in ASD	Variant categories observed	Log2(FC)	q-value
CELF6	Genetic association/Rare single gene variant/Functional	Deletions	−0.465	0.025
GALNT13	Rare single gene variant		−0.429	0.004
ARHGAP15	Rare single gene variant	Deletions, other	−0.529	0.003
CHRNB3	Rare single gene variant		−0.962	0.046
NELL1	Genetic association		−0.386	0.008
PCDH15	Genetic association		0.637	0.001
ADCY5	Rare single gene variant	Deletions, missense mutations	−0.365	0.016
AGMO	Genetic association		0.501	0.042
DOCK10	Rare single gene variant		0.529	0.001
PTCHD1	Rare single gene variant		−0.350	0.049
SYN2	Genetic association		0.401	0.016
CADPS2	Rare single gene variant	Deletions, missense mutations, other	−0.325	0.049
GPR37	Rare single gene variant		0.524	0.001
GRIK2	Genetic Association		−0.531	0.001
IL1RAPL1	Rare single gene variant		−0.402	0.012
KANK1	Rare single gene variant		0.586	0.001
AHI1	Rare single gene variant	Deletions, duplications, missense mutations, other	−0.648	0.001
CHD2	Multigenic CNV		−0.374	0.039
CNTN5	Rare single gene variant		−0.533	0.001
CNTNAP2	Syndromic		−0.341	0.037
CREBBP	Syndromic		−0.324	0.050
CTTNBP2	Rare single gene variant		−0.405	0.005
DCX	Rare single gene variant		−0.590	0.001
DHCR7	Syndromic		0.818	0.001
DMD	Genetic association		−0.372	0.011
FOXG1	Syndromic		−0.410	0.031
FOXP1	Rare single gene variant		−0.391	0.007
FOXP2	Rare single gene variant		−1.019	0.001
HEPACAM	Rare single gene variant		0.433	0.006
LAMC3	Rare single gene variant		0.600	0.007
RELN	Genetic association		−0.414	0.007
SLC16A3	Rare single gene variant		0.912	0.006