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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biochimie. 2015 Mar 10;117:15–21. doi: 10.1016/j.biochi.2015.03.001

FIGURE 1. Modes of lncRNA degradation.

FIGURE 1

Schematic of the major mechanisms of lncRNA decay. Top, LncRNAs are degraded by many miRNAs, decay-promoting RBPs (HuR, AUF1, IGF2BP, and UPF1), and general decapping enzymes and dadenylases (Dcp2, Dcp1, and CNOT1). Bottom, lncRNAs are protected from degradation by stabilizing RBPs (HuD and PABPN1).