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. Author manuscript; available in PMC: 2015 Sep 10.
Published in final edited form as: Prog Brain Res. 2014;211:141–164. doi: 10.1016/B978-0-444-63425-2.00006-4

FIGURE 4.

FIGURE 4

Functional connectome analysis of DA neuron connections in striatum. Mice are generated with ChR2 expressed selectively in DA neurons. DA neuron cell bodies are shown in the ventral midbrain (left) with their axons projecting into the median forebrain bundle (mfb) toward the striatum. In the striatum (right), spiny projection neurons (SPNs) and cholinergic interneurons (ChIs) are recorded and DA neuron inputs activated by wide-field photostimulation (larger circle around cells and terminals). With repeated measurements, the incidence and strength of DA neuron inputs to SPNs and ChIs are quantitated to determine functional connectivity.