Table 1. Pain and sedation scores (median and lower-upper range) measured prior to surgery (ie, baseline) and at 0.5, 1, 2, 4, 6, 8, 12, 18, 24, 32, 40, 48, 56, 64 and 72 hr after tracheal extubation in dogs undergoing mastectomy treated with gabapentin (Gabapentin) or placebo (Placebo).
| Time | VAS |
GMCPS |
Sedation scores |
|||
|---|---|---|---|---|---|---|
| Gabapentin | Placebo | Gabapentin | Placebo | Gabapentin | Placebo | |
| Baseline | 0 (0–0) | 0 (0–0) | 0.08 (0.08–0.08) | 0.08 (0.08–0.87) | 0 (0–0) | 0 (0–0) |
| 0.5 hr | 0 (0–20) | 0 (0–30) | 2.43 (0.08–3.81) | 2.43 (0.08–5.56) | 3 (0–4)a) | 3 (1–4)a) |
| 1 hr | 0 (0–10) | 5 (0–50) | 2.43 (0.08–3.55) | 1.99 (0.08–3.81) | 3 (0–4)a) | 2.5 (0–4)a) |
| 2 hr | 0 (0–30) | 20 (0–30) | 2.43 (0.87–3.55)a) | 2.53 (0.87–3.55)a) | 1 (0–3)a) | 1.5 (0–4)a) |
| 4 hr | 5 (0–30) | 20 (0–60) | 1.89 (0.08–3.37) | 3.08 (0.08–4.55) | 1 (0–3)a) | 0 (0–1) |
| 8 hr | 10 (0–50) | 10 (0–30) | 1.04 (0.08–5.85) | 1.35 (0.08–3.66) | 0 (0–1) | 0 (0–0) |
| 12 hr | 10 (0–50) | 5 (0–30) | 1.43 (0.08–4.05) | 0.6 (0.08–3.58) | 0 (0–0) | 0 (0–0) |
| 18 hr | 5 (0–30) | 0 (0–30) | 0.6 (0.08–3.56) | 0.08 (0.08–3.83) | 0 (0–0) | 0 (0–0) |
| 24 hr | 0 (0–30) | 0 (0–80) | 0.49 (0.08–3.81) | 0.08 (0.08–4.99) | 0 (0–0) | 0 (0–0) |
| 32 hr | 0 (0–10) | 0 (0–20) | 0.08 (0.08–1.46) | 0.08 (0.08–2.64) | 0 (0–0) | 0 (0–0) |
| 40 hr | 0 (0–10) | 0 (0–20) | 0.08 (0.08–1.20) | 0.08 (0.08–1.83) | 0 (0–0) | 0 (0–0) |
| 48 hr | 0 (0–10) | 0 (0–10) | 0.08 (0.08–1.21) | 0.08 (0.08–0.08) | 0 (0–0) | 0 (0–0) |
| 56 hr | 0 (0–20) | 0 (0–30) | 0.08 (0.08–1.46) | 0.08 (0.08–2.43) | 0 (0–0) | 0 (0–0) |
| 64 hr | 0 (0–20) | 0 (0–10) | 0.08 (0.08–1.20) | 0.08 (0.08–2.43) | 0 (0–0) | 0 (0–0) |
| 72 hr | 0 (0–20) | 0 (0–10) | 0.08 (0.08–1.20) | 0.08 (0.08–2.33) | 0 (0–0) | 0 (0–0) |
a) Differences from baseline in each group (Friedman test, P<0.05). VAS=Visual Analogue scale (0–100 mm); GMCPS= Glasgow Modified Composite Pain Score (0–10).