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. 2015 Aug 28;6(10):1020–1029. doi: 10.7150/jca.12733

Fig 3.

Fig 3

Effects of 10 or 100 μM zoledronate treatment on protein and mRNA expressions of collagenases. A) MMP-8 expression on western blotting at day 2 or 3 and representative western blots. Relative expressions of MMP-8 were expressed as mean ± S.E.M. (n=4) * P ≤ 0.05, C versus Z100; + P ≤ 0.05 Z10 vs Z100; Paired Student's t-test. B) Immunopositivity scores of MMP-8 and representative photomicrographs of PC3 cells stained with MMP-8 antibody immunocytochemically at day 3. Immunpositivity scores were expressed as mean ± S.E.M. (n=4) ** P ≤ 0.01, C versus Z100 Chi-square test. C) MMP-8 mRNA expressions at day 3. mRNA fold changes were expressed as mean ± S.E.M. (n=4) *** P ≤ 0.001 C versus Z100 Paired Student's t-test. D) MMP-13 mRNA expressions at day 3. mRNA fold changes were expressed as mean ± S.E.M. (n=4) C: Control, Z10: 10 μM zoledronate, Z100: 100 μM zoledronate.