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Effects of 100 μM zoledronate treatment on mRNA expressions of KRAS 4A, KRAS 4B, AKT-1, ERK1, BCLX, PCA-1, JNK1 and p38. Real-time PCR was performed on reverse-transcribed RNA isolated from control and 100 μM zoledronate-treated cells at day 3. mRNA fold changes were expressed as mean ± S.E.M. (n=4) * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, C versus Z100 Paired Student's t-test. C: Control, Z100: 100 μM zoledronate.
