Table 2.

Single SNP analysis of the relationship between TLR polymorphisms and congenital Toxoplasma gondii infection

Gene polymorphism	Genetic model	Genotype	Genotype prevalence rates; n (%)a		ORb (95 % CI)c	p-Valued
			Infected cases	Uninfected controls
TLR4 896 A>G	Codominant	AA	18 (94.7 %)	47 (94 %)	1.00	0.420
		AG	1 (5.3 %)	1 (2 %)	2.61 (0.15–44.01)
		GG	0 (0 %)	2 (4 %)	0.00 (0.00–NA)
	Dominant	AA	18 (94.7 %)	47 (94 %)	1.00	0.910
		AG-GG	1 (5.3 %)	3 (6 %)	0.87 (0.08–8.92)
	Recessive	AA-AG	19 (100 %)	48 (96 %)	1.00	0.250
		GG	0 (0 %)	2 (4 %)	0.00 (0.00–NA)
	Overdominant	AA-GG	18 (94.7 %)	49 (98 %)	1.00	0.490
		AG	1 (5.3 %)	1 (2 %)	2.72 (0.16–45.85)
	Log-additive	–	–	–	0.66 (0.12–3.75)	0.620
TLR4 1196 C>T	Codominant	CC	17 (94.4 %)	36 (87.8 %)	1.00	0.450
		CT	1 (5.6 %)	3 (7.3 %)	0.71 (0.07–7.3)
		TT	0 (0 %)	2 (4.9 %)	0.00 (0.00–NA)
	Dominant	CC	17 (94.4 %)	36 (87.8 %)	1.00	0.410
		CT-TT	1 (5.6 %)	5 (12.2 %)	0.42 (0.05–3.91)
	Recessive	CC-CT	18 (100 %)	39 (95.1 %)	1.00	0.220
		TT	0 (0 %)	2 (4.9 %)	0.00 (0.00–NA)
	Overdominant	CC-TT	17 (94.4 %)	38 (92.7 %)	1.00	0.800
		CT	1 (5.6 %)	3 (7.3 %)	0.75 (0.07–7.69)
	Log-additive	–	–	–	0.43 (0.07–2.78)	0.300
TLR9 1635 G>A	Codominant	AA	5 (25 %)	15 (34.1 %)	1.00	0.760
		GA	11 (55 %)	21 (47.7 %)	1.57 (0.45–5.47)
		GG	4 (20 %)	8 (18.2 %)	1.50 (0.31–7.21)
	Dominant	AA	5 (25 %)	15 (34.1 %)	1.00	0.460
		GA-GG	15 (75 %)	29 (65.9 %)	1.55 (0.47–5.09)
	Recessive	AA-GA	16 (80 %)	36 (81.8 %)	1.00	0.860
		GG	4 (20 %)	8 (18.2 %)	1.12 (0.3–4.28)
	Overdominant	AA-GG	9 (45 %)	23 (52.3 %)	1.00	0.590
		GA	11 (55 %)	21 (47.7 %)	1.34 (0.46–3.87)
	Log-additive	–	–	–	1.25 (0.59–2.68)	0.560

p ≤ 0.050 is considered significant

^a n number of examined fetuses and newborns

^b OR odds ratio

^c CI confidence interval

^dLogistic regression model