Figure 1.

Half-maximal inhibitory concentration (IC₅₀) values for class II HLA-DRB1*03:01, *03:02, *11:01, and *12:01 allelic epitopes for selected proteins previously shown to be associated with sarcoidosis. IC₅₀ values are plotted for all possible 15-mer peptides across the amino acid sequences of ESAT6 (Mycobacterium tuberculosis) (A), T KatG (M. tuberculosis) (B), HSP70 (M. tuberculosis) (C), soda (M. tuberculosis) (D), trigger factor (Propionibacterium acnes) (E), and MAP2694 (Mycobacterium avium ssp. paratuberculosis K-10) (F). The dashed line on each graph represents an IC₅₀ binding threshold of 50 nM, which is considered strong binding.