Table 2.

Associations^* between HLA–DRB1 Two-Field Alleles and Evidence of Persistent Radiographic Disease^†

	Allele Frequency		Full Sample		Study-Specific ORs (95% CI)
Allele	Resolved (n = 308)	Persistent (n = 624)	OR* (95% CI)*	P Value*	ACCESS‡	SAGA‡	HFH‡	Phet
01:02	0.064	0.046	0.63 (0.41–0.96)	0.032	–§	0.55 (0.30–1.02)	0.75 (0.41–1.39)	0.761
03:02	0.130	0.078	0.52 (0.37–0.72)	1.3 × 10−4	0.27 (0.08–0.90)	0.62 (0.38–0.99)	0.46 (0.27–0.79)	0.418
11:01	0.139	0.175	1.41 (1.04–1.91)	0.028	4.16 (1.12–15.50)	1.19 (0.77–1.83)	1.53 (0.96–2.43)	0.271
15:01	0.016	0.034	2.25 (1.07–4.74)	0.033	–§	3.16 (0.89–11.28)	1.70 (0.65–4.45)	0.507

For definition of abbreviations, see Table 1.

^*Associations with P < 0.05. Models were estimated using generalized estimating equations, and the allele odds ratios are estimated assuming a dominant model adjusted for sex and genome-wide percent African ancestry. P values were calculated using a Wald test.

^†Based on chest radiographs assessed after a minimum of 2 years of follow–up.

^‡The study-specific sample sizes are as follows: ACCESS (n = 78; 24 resolved and 54 persistent), SAGA (n = 469; 142 resolved and 327 persistent), and HFH (n = 385; 142 resolved and 243 persistent).

^§Not estimable.