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. 2015 Aug;53(2):206–216. doi: 10.1165/rcmb.2014-0227OC

Table 3.

HLA-DRB1 Two-Field Sarcoidosis Risk Allele Associations Stratified by Local African Ancestry* at the DRB1 Locus

Allele Local Ancestry* Case Control OR (95% CI) P Value Persistent Resolved OR (95% CI) P Value
03:01 2 0.034 0.058 0.54 (0.39–0.75) 2.1 × 10−4 0.034 0.031 1.10 (0.59–2.07) 0.759
  1 0.061 0.106 0.54 (0.34–0.860) 0.009 0.028 0.078 0.29 (0.09–0.90) 0.032
  0 0.173 0.095 2.18 (0.72–6.60) 0.166 0.167 0.200
    Pint= 0.050
  Pint= 0.146
 
03:02 2 0.097 0.089 1.10 (0.88–1.38) 0.415 0.085 0.137 0.56 (0.39–0.80) 0.002
  1 0.069 0.031 2.39 (1.36–4.18) 0.002 0.056 0.108 0.44 (0.18–1.10) 0.080
  0 0 0 0 0
    Pint= 0.009
  Pint= 0.656
 
11:01 2 0.191 0.130 1.73 (1.43–2.09) 2.1 × 10−8 0.197 0.159 1.32 (0.95–1.83) 0.100
  1 0.094 0.060 1.68 (1.07–2.64) 0.024 0.120 0.059 2.80 (1.01–7.74) 0.048
  0 0.058 0.071 0.72 (0.16–3.31) 0.678 0.083 0
    Pint= 0.583
  Pint= 0.172
 
12:01 2 0.083 0.043 2.08 (1.58–2.73) 1.4 × 10−7 0.087 0.081 1.02 (0.67–1.56) 0.915
  1 0.057 0.027 2.31 (1.25–4.26) 0.007 0.060 0.059 0.93 (0.33–2.63) 0.889
  0 0.019 0.012 1.25 (0.10–15.69) 0.861 0 0
    Pint= 0.939   Pint= 0.970  

Definition of abbreviations: CI, confidence interval; OR, odds ratio; Pint, Wald test P value for the allele-by–local ancestry interaction term(s).

*

Local African ancestry indicates the inferred number of African ancestral alleles present at the DRB1 locus for each subject.

Not estimable.