Table 4.

Associations between HLA-DRB1*03:01 and *03:02 Alleles and Organ Involvement at Disease Presentation

		Cases
Allele	Organ Involvement	n	Allele Frequency	OR*	95% CI	P Value
03:01	Lung	749	0.037	0.48	0.34–0.67	1.6 × 10−5
	Nonthoracic	729	0.041	0.55	0.40–0.75	1.7 × 10−4
	Nonthoracic lymph node	192	0.020	0.21	0.09–0.48	2.2 × 10−4
	Ocular	258	0.028	0.34	0.19–0.61	2.6 × 10−4
	Skin	384	0.043	0.60	0.41–0.88	0.009
	Liver	176	0.037	0.54	0.30–0.96	0.037
03:02	Skin	384	0.103	1.50	1.12–2.02	0.007

Definition of abbreviations: CI, confidence interval; OR, odds ratio.

^*Statistical comparisons based on 1,467 unaffected controls with allele frequencies of 0.069 and 0.072 for DRB1*03:01 and *03:02, respectively.