Table 6.

Listing of Specific Peptides in Putative Sarcoidosis-Causing Organisms with the Strongest In Silico Computed Binding Affinities to Selected HLA-DRB1 Alleles

Organism	Protein	Position	Peptide	Rank*	Position	Peptide	Rank*
		*03:01			*03:02
Mycobacterium tuberculosis	ESAT6	63–77	TELNNALQNLARTIS	4.45	15–29	ASAIQGNVTSIHSLL	11.06
M. tuberculosis	KatG	9–23	ATWLGDERYSGKRDL	1.97	51–65	AAVDIRETFRRMAMN	3.34
M. tuberculosis	HSP70	358–372	GEVKDVLLLDVTPLS	0.01	141–155	VLRIVNEPTAAALAY	2.28
M. tuberculosis	SodA	56–70	HSAILLNEKNLAFNL	0.19	56–70	HSAILLNEKNLAFNL	0.52
Propionibacterium acnes	Trigger factor	256–270	FDTVDEMRADLRTAL	0.13	259–273	VDEMRADLRTALENM	0.54
Mycobacterium avium ssp. paratuberculosis	MAP2694	311–325	VTIIAVDTKPVSVFI	0.22	311–325	VTIIAVDTKPVSVFI	1.99
		*11:01			*12:01
M. tuberculosis	ESAT6	63–77	TELNNALQNLARTIS	1.64	63–77	TELNNALQNLARTIS	21.65
M. tuberculosis	KatG	53–67	VDIRETFRRMAMNDV	3.42	23–37	LENPLAAVQMGLIYV	19.55
M. tuberculosis	HSP70	90–104	EISARILMKLKRDAE	0.32	93–107	ARILMKLKRDAEAYL	7.27
M. tuberculosis	SodA	100–114	ADAFGSFDKFRAQFH	1.82	56–70	HSAILLNEKNLAFNL	5.58
P. acnes	Trigger factor	264–278	ADLRTALENMARLDQ	0.65	2–16	PSSLEKLSTNRVKLT	10.72
M. avium ssp. paratuberculosis	MAP2694	128–142	LVVLAVIALVATLVV	0.32	337–351	GLIGKIIAALKVAKS	1.34

^*Ranking of peptide–allele binding affinity as a percentile among binding affinities of all DRB1 alleles and all possible protein peptides.