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CLC3 dependence of cytokine-induced O2∙− release in blood eosinophils. (A–D) Effect of TGF-β1, TGF-β2, eotaxin-1, and eotaxin-3 on O2∙− release, respectively. The CLC3 blocker NPPB inhibited the increase in O2∙− release. However, diphenyleneiodonium (DPI) blocked the O2∙− release in all except eotaxin-3–induced eosinophils, where it partially blocked the 20-minute burst and delayed the second burst (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
