Figure 5.

Effect of chemokine (C-C motif) receptor 3 (CCR3) blocker on eotaxin-induced O₂^∙− release in blood eosinophils. CCR3 blocker (SB328437, 100 μM) had no effect on the first burst, but it increased the O₂^∙− release alone and in the presence of eotaxin-1 and eotaxin-3. However, there was a delay in the second oxidative burst, suggesting activation of an alternate pathway. At the peak of the eotaxin-induced second oxidative burst, there was significant difference in released O₂^∙− with the CCR3 blocker groups (n = 3). *P < 0.05, **P < 0.01, and ****P < 0.0001.