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. 2015 Aug;53(2):255–264. doi: 10.1165/rcmb.2014-0351OC

Figure 4.

Figure 4.

(A) Responses to the endothelium-dependent vasodilator acetylcholine (ACh) in small pulmonary arteries from control (normoxic) and chronically hypoxic piglets. Small pulmonary arteries from normoxic control piglets dilated to ACh (n = 10); ACh elicited a similar degree of constriction in small pulmonary arteries from all groups of hypoxic piglets, whether untreated (n = 6) or treated with low-dose (n = 3) or high-dose (n = 4) L-citrulline (Cit). *Different from control (normoxia) (P < 0.05; ANOVA with post hoc comparison test). (B) Responses to the nitric oxide (NO) synthase antagonist Nω-nitro-L-arginine methylester (l-NAME) in small pulmonary arteries from control (normoxic) and chronically hypoxic piglets. Responses to l-NAME were less for small pulmonary arteries from the untreated group of hypoxic piglets (n = 8) than for any other group of piglets. Small pulmonary arteries from low-dose (n = 3) and high-dose (n = 10) L-citrulline–treated groups of chronically hypoxic piglets had responses to l-NAME that were similar to normoxic control piglets (n = 12). *Different from control (normoxia); +different from untreated chronic hypoxia (P < 0.05; ANOVA with post hoc comparison test). (C) Responses to the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) in small pulmonary arteries from control (normoxic) and chronically hypoxic piglets. Responses to SNAP were less for small pulmonary arteries from the untreated group of hypoxic piglets (n = 9) than for any other group of piglets. Small pulmonary arteries from low-dose (n = 5) and high-dose (n = 9) L-citrulline–treated groups of chronically hypoxic piglets had responses to SNAP that were greater than untreated hypoxic piglets. Responses to SNAP were similar for small pulmonary arteries from normoxic control piglets (n = 10) and high-dose L-citrulline–treated chronically hypoxic piglets. *Different from control (normoxia); +different from untreated chronic hypoxia; !different from low-dose L-citrulline–treated chronic hypoxia (P < 0.05; ANOVA with post hoc comparison test).