Figure 7.

Representative Western blot for phospho-eNOS (Ser¹¹⁷⁷) (p-eNOS), eNOS, and β-actin (A) and corresponding densitometry (B and C) show that small pulmonary arteries from low-dose and high-dose L-citrulline–treated groups of piglets had greater p-eNOS/eNOS ratios than untreated hypoxic animals. The p-eNOS/eNOS ratios were greater in pulmonary arteries from high-dose compared with low-dose L-citrulline–treated chronically hypoxic piglets. eNOS/β actin expression was similar in small pulmonary arteries from all groups of piglets. *Different from control (normoxia); ⁺different from untreated chronic hypoxia; ^!different from low-dose L-citrulline–treated chronic hypoxia (P < 0.05; ANOVA with post hoc comparison test).