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. 2015 Sep;53(3):391–399. doi: 10.1165/rcmb.2014-0150OC

Figure 6.

Figure 6.

IPF fibroblastic foci contain a paucity of HDAC4 immunoreactive cells. IPF (A and B) and control (C and D) human lung tissue specimens (n = 3 each) were analyzed for HDAC4 immunoreactivity by immunohistochemistry. (A) Representative image of immunohistochemistry of IPF lung tissue demonstrating a paucity of HDAC4-expressing cells in the IPF fibrotic reticulum. (B) Negative control: IPF lung tissue stained with secondary antibody only. (C) Numerous HDAC4-expressing cells were detected in alveolar structures of anatomically normal control lung tissue. Arrows point to HDAC4 immunoreactive cells. Inset: High-power image of a cell displaying nuclear HDAC4 immunoreactivity. (D) Negative control: control lung tissue stained with secondary antibody only. Scale bar, 50 μm.