Figure 2.

RELMα KO prevents OVA challenge–induced increases in pulmonary pressure and cardiac hypertrophy. (A) Right ventricular systolic pressure (RVSP), which was measured 1 day after the last OVA challenge, increased significantly in WT mice after 3 weeks of intermittent OVA challenge (OVA versus saline [Sal], P = 0.05). Retnla KO abolished the effect of OVA on pulmonary artery pressure. (B) Fulton index was determined as the ratio of right ventricle (RV) weight to left ventricle plus septum (LV + S) weight. The Fulton index increased significantly in WT animals (OVA versus Sal, *P < 0.05) but not in Retnla^−/− animals after OVA challenge. Data are presented as mean (±SEM).