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. 2015 Sep 11;5:14060. doi: 10.1038/srep14060

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(a) Distribution of deleterious mutations identified in the CRC discovery cohort (red dots) and replication cohort (black dots) in BLM. Structural domains of the protein are indicated in colours. (b) Pedigrees of the individuals with deleterious BLM mutations. An arrow indicates the proband. Individuals with cancer and their age at diagnosis (if known) are marked as follows: breast cancer (B), bladder cancer (BC), brain tumour (BT), colon cancer (C), endometrial cancer (Ed), leukaemia (Leu), liver cancer (LC), pancreas cancer (Pa), melanoma (Me), prostate cancer (PC) and cancer of unknown origin (Ca).