Table 2. Enrichment analyses for known deleterious BLM mutations in early-onset CRC cases compared to a cohort of population-matched controls in in-house and public databases.

	Control cohort (1/532)	In-house control exomesa (2/2,329)	ExACb (71/61,486)
	OR: 8.67	OR: 18.99	OR: 14.15
Replication cohort (3/185)	95% CI, 0.69–455.36	95% CI, 2.17–227.56	95% CI, 2.85–43.37
	P = 0.05516	P = 0.003534	P = 0.001482

^aIn-house data set of sequenced exomes;

^bExAC, Exome Aggregation consortium¹⁰;

Abbreviations: OR, odds ratio; CI, confidence interval.