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. 2015 May 14;32(8):2161–2180. doi: 10.1093/molbev/msv118

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Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution 2015. This work is written by US Government employees and is in the public domain in the US.

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Fig. 2. — Distributions of KMPs/RSPs in enhancers. (A) Examples of a SNP associated with trait of HDL cholesterol in fKMPs. rs605066 is likely to be a causal SNP for the trait of HDL cholesterol. This position associates with the strongly conserved nucleotide C of the FOXA2 binding site and it does overlap with a FOXA2 ChIP-seq peak. This SNP is also in the LD blocks of two SNPs with liver-related traits (mean corpuscular hemoglobin and adponectin levels). (B) The boxplot demonstrates enhancer content of KMP, RSP, fKMP, and fRSP. (C) The number of fKMP clusters per enhancer is positively correlated with the number of fRSP clusters per enhancer (R²= 0.642; PCC = 0.8). (D) The number of KMP clusters per enhancer is positively correlated with the number of RSP clusters per enhancer (R²= 0.93; PCC = 0.96).