Fig. 3.

KM SNPs tend to coexist in TFBS clusters. Values in the heat map represent the log (ratio of the fraction of TF pairs both having a KM SNP to the fraction of random TF pairs both having a KM SNP), that is, the log-ratio of proportion of TFBS clusters overlaying KM SNPs associated with certain TF pairs to the product of that overlaying KM SNPs associated with each TF separately (Materials and Methods). The red rectangle focuses on the coexistence of binding sites of HNF4A-FOXA1. The nucleotide colored in red within the parenthesis is the reference allele; the one colored in gray is the alternative allele (KM allele).