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. 2015 Sep 11;5:14055. doi: 10.1038/srep14055

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Longitudinal MPI imaging of 5 × 10⁵ SPIO-labeled human NPCs implanted in the forebrain cortex (Animals 1-2), near lateral ventricle (Animal 3), and equivalent SPIO-only tracer in the forebrain cortex as control (Animal 4). MPI imaging quantifies graft clearance and movement over time, with rapid total clearance of SPIO-only injection (MPI: 30 sec acquisitions, 9.3 cm × 6 cm FOV, color intensity in ng/mm², MRI reference: 10 min acquisitions, 7.5 cm × 4 cm, 384 × 384 matrix). All images are equally scaled; scale bar: 1 cm. (b) Total iron MPI estimates for in vivo cell grafts are plotted as a function of time with exponential fit. In vivo iron in Animal 1 and 2 do not show significant decrease over time, while iron signal was significantly decreased in Animal 3 starting Day 10. Animal 4 showed no long-term persistent MPI signal.