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. 2015 Sep 11;5:13982. doi: 10.1038/srep13982

Figure 11. DGLHD blocked JAK2-STAT3 signaling pathways, but not TLR4-mediated signaling pathway.

Figure 11

(A) DGLHD reduced JAK2 and STAT3 genes expression in pancreas, spleen, thymus and BMDCs. (B) The mRNA expression of the key molecules in TLR4-mediated MyD88-dependent pathway and TRIF-dependent pathway was not down-regulated by DGLHD as a whole in the pancreas. The samples come from 12 week-old NOD mice treated with DGLHD for 4 weeks from 8 until 12 weeks of age or model control animals. Data were presented as means ± SD (n = 3). *P < 0.05, **P < 0.01 compared with the model control group.