Table 3. Brain-to-Blood (K_b,brain) and Brain-to-Plasma (K_p,brain) Concentration Ratios for Total Radioactivity as Well as for Unchanged Parent Tracer (K_p,brain,VPM or K_p,brain,dLOP) in Vehicle Treated and Tariquidar Treated (15 mg/kg) Wild-Type FVB/N Mice Determined at 25 min after Injection of Either (R)-[¹¹C]Verapamil or [¹¹C]-N-Desmethyl-loperamide under Long (160 min) and Short (5 min) Isoflurane Anesthesia^a.

	long anesthesia (160 min)			short anesthesia (5 min)
	vehicle	tariquidar 15 mg/kg	fold increase	vehicle	tariquidar 15 mg/kg	fold increase
(R)-[11C]Verapamil
n	4	3		4
Kb,brain	0.44 ± 0.07	2.24 ± 0.49	5.1	0.52 ± 0.07	nd	nd
Kp,brain	0.29 ± 0.04	1.53 ± 0.30	5.2	0.35 ± 0.06	nd	nd
Kp,brain,VPM	0.27 ± 0.12	3.83 ± 0.30	14.1	0.29 ± 0.18	nd	nd
[11C]-N-Desmethyl-loperamide
n	3	3		4	3
Kb,brain	0.23 ± 0.04	0.93 ± 0.01	4.0	0.22 ± 0.01	1.57 ± 0.10c	7.0
Kp,brain	0.18 ± 0.04	0.67 ± 0.01	3.7	0.20 ± 0.01	1.32 ± 0.10c	6.6
Kp,brain,dLOP	0.40 ± 0.16	7.34 ± 0.58	18.3	0.51 ± 0.18	4.85 ± 0.29b	9.6

^aAll data are given as mean ± SD; nd = not determined.

^bP < 0.05 when compared to corresponding long anesthesia group (2-tailed t-test).

^cP < 0.001 when compared to corresponding long anesthesia group (2-tailed t-test).