Performance of a rhenium oxide powder, ReO3, as an assisting ionization material for small molecule analytes in positive LDI mode for a) 500 pg/μL protonated cocaine with its major fragment, b) 500 pg/μL protonated quinuclidine, c) 500 pg/μL protonated ametryn, and d) radical ions of a polyaromatic hydrocarbon (PAH) standard mixture with the four hydrocarbons chrysene (m/z 228), benzo [k] fluoranthene (m/z 252), benzo [ghi] perylene (m/z 276), and dibenz [a,h] anthracene (m/z 279) at 250 pg/μL each. Metal oxide particle suspensions were mixed 1:1 with each analyte (concentrations listed above after mixing) and 1 μL spotted on plate. Each case above provides the highest and cleanest signal among all particles explored with each analyte. 254×188mm (150 × 150 DPI)