Table 4.
Parameter | Both tests combined (independence) | Both tests combined (dependence) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
HRV test | Ewing’s test | P value | HRV test | Ewing’s test | P value | |||||
Mean | SE | Mean | SE | Mean | SE | Mean | SE | |||
Sensitivity | 0.830 | 0.070 | 0.872 | 0.056 | 0.035 | 0.812 | 0.086 | 0.845 | 0.066 | 0.086 |
Specificity | 0.833 | 0.063 | 0.744 | 0.077 | 0.000 | 0.792 | 0.075 | 0.700 | 0.091 | 0.006 |
Accuracy | 0.832 | 0.049 | 0.808 | 0.049 | 0.001 | 0.802 | 0.063 | 0.772 | 0.062 | 0.011 |
PPV | 0.786 | 0.091 | 0.715 | 0.104 | 0.002 | 0.720 | 0.119 | 0.649 | 0.136 | 0.016 |
NPV | 0.862 | 0.072 | 0.882 | 0.059 | 0.005 | 0.853 | 0.089 | 0.866 | 0.068 | 0.019 |
Non-inferiority test to test the hypothesis of performance of HRV test inferior to Ewing’s test; delta >0 is the non-inferiority margin of clinical interest, which is set as quarter of value of parameter of Ewing’s test in this study. PPV positive predictive value, NPV negative predictive value