Table 4.

Comparison of performance of HRV test and Ewing’s test in combined both tests

Parameter	Both tests combined (independence)					Both tests combined (dependence)
	HRV test		Ewing’s test		P value	HRV test		Ewing’s test		P value
	Mean	SE	Mean	SE		Mean	SE	Mean	SE
Sensitivity	0.830	0.070	0.872	0.056	0.035	0.812	0.086	0.845	0.066	0.086
Specificity	0.833	0.063	0.744	0.077	0.000	0.792	0.075	0.700	0.091	0.006
Accuracy	0.832	0.049	0.808	0.049	0.001	0.802	0.063	0.772	0.062	0.011
PPV	0.786	0.091	0.715	0.104	0.002	0.720	0.119	0.649	0.136	0.016
NPV	0.862	0.072	0.882	0.059	0.005	0.853	0.089	0.866	0.068	0.019

Non-inferiority test to test the hypothesis of performance of HRV test inferior to Ewing’s test; delta >0 is the non-inferiority margin of clinical interest, which is set as quarter of value of parameter of Ewing’s test in this study. PPV positive predictive value, NPV negative predictive value