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. 2015 Jul 30;290(37):22649–22661. doi: 10.1074/jbc.M115.658468

FIGURE 2.

FIGURE 2.

HBXIP activates the P2 promoter of MDM2 in breast cancer cells. A, locations of P1 and P2 of the MDM2 promoter are shown. B, the promoter (P1 and P2) activities of MDM2 were examined by luciferase reporter gene assays in MCF-7 cells transfected with pCMV-HBXIP plasmids. NS, not significant. C and D, the promoter (P2) activities of MDM2 were examined by luciferase reporter gene assays in MCF-7 and HEK293T cells transfected with pCMV-HBXIP plasmids. E, effect of HBXIP siRNA on promoter (P2) activities of MDM2 was detected by luciferase reporter gene assays in LM-MCF-7 cells. Each experiment was repeated at least three times. Student's t test; *, p < 0.05; **, p < 0.01.