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. 2015 Jul 28;290(37):22747–22758. doi: 10.1074/jbc.M115.648824

TABLE 1.

Affinities of different three-finger toxins toward nAChRs and acetylcholine-binding proteins

α7-nAChR is the human neuronal homopentameric nAChR, Tca-nAChR is the Torpedo californica muscle-type nAChR; Ac- and Ls-AChBP are L. stagnalis and Aplysia californica acetylcholine-binding proteins, respectively. ND means not determined.

Neurotoxin IC50
α7-nAChR Tca-nAChR Ac-AChBP Ls-AChBP
nm
α-Ctx 105 (24) 4.5 (24) 356 250
α-Bgt 3 1 250 (46) 1.8
NTI 34 (14) ND 1100 ND
WTX 3000 (15, 23) 14,800 (15, 23) ND ND
OWT 2000 (26) 30,000 (26) ND ND
NTII ≫10,000 (18, 25) 3 (18) ND ND