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EC50 values for GABA and IC50 values for α-Ctx at different combinations of GABAAR subunits
| Subunit combination | EC50 ± S.E. (95% confidence interval) | IC50 ± S.E. (95% confidence interval) |
|---|---|---|
| μm | nm | |
| α1β2γ2 | 35 ± 1 (33, 36) | 469 ± 23 (427, 515) |
| α1β3γ2 | 29 ± 7 (19, 44) | 236 ± 7 (223, 250) |
| α2β2γ2 | 45 ± 1 (43, 47) | 485 ± 39 (417, 564) |
| α2β3γ2 | 12 ± 1 (11, 13) | 1099 ± 57 (1016, 1088) |
| α5β3γ2 | 20 ± 2 (17, 24) | 635 ± 91 (489, 825) |
