FIGURE 10.

Putative role of the SOD2 induced in activated microglia. Mechanistic insight into the role of SOD2 up-regulation in activated microglia. SOD2 is up-regulated downstream of TLRs via NF-κB and AP-1. Increased SOD2 scavenges ROS, not only to protect microglia from the oxidative stress induced under inflammatory conditions, but also to decrease the inflammatory cytokine expression by suppressing the NF-κB activity. SOD2 regulates the microglial activity via an NF-κB-mediated feedback loop, terminating microglial activation.