Fig. 3.

Effects of verapamil and cytochalasins on SK human ovarian carcinoma cell lines. a Effects of verapamil on potentiating SK human ovarian carcinoma sensitivity to cytochalasins B, C, D, and 21,22-dihydrocytochalasin B. Cell lines are arranged in order of increasing drug resistance from left to right. The IC₉₀ concentrations are given in μM. Numbers in black refer to fold sensitization elicited by the addition of 30 μM verapamil. b Effects of cytochalasin A-alone or in combination with 30 μM verapamil against SKVCR0.015 cells. The values are taken as a percentage of 30 μM verapamil-treated cells. c Effects of cytochalasin B-alone or in combination with 30 μM verapamil against SKVCR0.015 cells. The values are taken as a percentage of 30 μM verapamil-treated cells. d Dose response of cytochalasin A-alone or in combination with 30 μM verapamil on the growth of SKVCR0.015 cells. e Dose response of cytochalasin B-alone or in combination with 30 μM verapamil on the growth of SKVCR0.015 cells. For panels d and e, agents were administered for either 48 or 96 h, as indicated in the graphs