Table 2.
Effects of clinically approved natural product antineoplastic agents and of cytochalasin congeners on drug-sensitive and multidrug-resistant human ovarian carcinoma lines
| Cell line | SKOV3a | SKVCR0.015 | SKVCR0.1 | SKVLB1 | |||
|---|---|---|---|---|---|---|---|
| IC concentrations (nM) at 96 h | IC90 | IC90 | RI | IC90 | RI | IC90 | RI |
| Doxorubicin | 11 | 125 | 11 | 125 | 11 | 2900 | 264 |
| Paclitaxel | 2.8 | 8 | 3 | 4 | 1.4 | 3900 | 1400 |
| Vinblastine | 1.9 | 10 | 5 | 20 | 10 | 3100 | 1600 |
| Cytochalasin A | 1000 | 1000 | 1 | 500 | 0.5 | 750 | 0.75 |
| Cytochalasin B | 2250 | 1500 | 0.67 | 1250 | 0.56 | 3000 | 1.33 |
| 21, 22-Dihydrocytochalasin B | 3000 | 2400 | 0.8 | 1600 | 0.53 | 5000 | 2.5 |
| 21, 22-Dihydrocytochalasin B γ-L | 40000 | 30000 | 0.75 | 30000 | 0.75 | 40000 | 1 |
| Cytochalasin C | 330 | 250 | 0.76 | 125 | 0.38 | 8000 | 24 |
| Cytochalasin D | 80 | 80 | 1 | 320 | 4 | 8000 | 100 |
| Cytochalasin E | 200 | ND | ND | 1600 | 8 | ||
| Cytochalasin H | 100 | ND | ND | 1600 | 16 | ||
| Cytochalasin J | 800 | ND | ND | 3200 | 4 | ||
ND not determined, RI resistance index compared to parental SKOV3 line
aRI = 1 for all agents for SKOV3 line