Table 3.
Changes in BMF grade from baseline for individual patients, according to disease subtype and treatment cycle
| Disease subtype | BMF grade | Change in BMF grade from baseline to last time point evaluated | |||||
|---|---|---|---|---|---|---|---|
| Baseline (n = 21) | Cycle 6 (n = 18) | Cycle 12 (n = 16) | Cycle 18 (n = 14) | Cycle 24 (n = 9) | Cycle 30 (n = 9) | ||
| PMF | 3 | 2 | n/a | n/a | n/a | n/a | Improved |
| PMF | 3 | 2 | 1 | 1 | n/a | 1 | Improved |
| PMF | 3 | 3 | n/a | 3 | n/a | n/a | Persistent grade 3 |
| PMF | 3 | 3 | n/a | n/a | n/a | n/a | Persistent grade 3 |
| PMF | 3 | 2 | 3 | n/a | 2 | 2 | Improved |
| PMF | 3 | 2 | 2 | 2 | 2 | n/a | Improved |
| PMF | 2 | 3 | 3 | n/a | n/a | n/a | Worsened |
| PMF | 2 | 2 | 2 | 2 | n/a | n/a | Stabilised |
| PMF | 2 | n/a | 3 | n/a | n/a | n/a | Worsened |
| PMF | 2 | n/a | 3 | n/a | n/a | n/a | Worsened |
| PMF | 1 | 1 | 2 | 1 | 1 | 1 | Stabilised |
| PMF | 1 | n/a | 0 | 0 | 0 | n/a | Improved |
| Post-PV MF | 3 | 2 | 2 | 3 | n/a | n/a | Persistent grade 3 |
| Post-PV MF | 3 | 3 | n/a | 3 | 3 | 3 | Persistent grade 3 |
| Post-PV MF | 3 | 2 | 3 | 3 | 3 | n/a | Persistent grade 3 |
| Post-PV MF | 2 | 3 | 2 | 2 | n/a | 2 | Stabilised |
| Post-PV MF | 2 | 1 | 0 | 0 | n/a | 0 | Improved |
| Post-PV MF | 2 | 3 | 3 | 3 | 2 | 3 | Worsened |
| Post-PV MF | 2 | 2 | 3 | n/a | 2 | 2 | Stabilised |
| Post-PV MF | 2 | 2 | 2 | 2 | 1 | 1 | Improved |
| Post-ET MF | 2 | 1 | n/a | 3 | n/a | n/a | Worsened |
n/a not applicable